The treaty of Zaragoza was a 1529 follow-up to the Treaty of Tordesillas. In Tordesillas, Spain and Portugal drew a line to divide the Western hemisphere. West of an arbitrary meridian: Spanish domain. East: Portuguese domain.
(Of course, nobody else had a say in this division.)
In 1529, the Portuguese discovered the Moluccas, islands right to the West of New Guinea. The Spanish wanted the Moluccas too, so they resorted to claiming that Tordesillas divided the whole Earth into two equal hemispheres
Initially, the line of demarcation did not encircle the Earth. Instead, Spain and Portugal could conquer any new lands they were the first to discover, Spain to the west and Portugal to the east, even if they passed each other on the other side of the globe. But Portugal’s discovery of the highly valued Moluccas in 1512 caused Spain to argue in 1518 that the Treaty of Tordesillas divided the Earth into two equal hemispheres.
So, what made the Moluccas so valuable that they were worth reconsidering the world order agreed by the Spanish and the Portuguese?
Though long-used in traditional medicine, there is little evidence that clove oil containing eugenol is effective for toothache pain or other types of pain. – Wikipedia